Keiji Tanaka Selected Research

PTEN-induced putative kinase

10/2018	Structural insights into ubiquitin phosphorylation by PINK1.
3/2015	Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment.
6/2014	Ubiquitin is phosphorylated by PINK1 to activate parkin.
12/2013	A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.
10/2010	Uncovering the roles of PINK1 and parkin in mitophagy.

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Keiji Tanaka Research Topics

Disease

15	Parkinsonian Disorders (Parkinsonism) 10/2018 - 03/2003
14	Parkinson Disease (Parkinson's Disease) 11/2021 - 10/2003
13	Neoplasms (Cancer) 10/2019 - 01/2002
12	Type 2 Diabetes Mellitus (MODY) 03/2020 - 01/2002
11	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2020 - 12/2004
11	Myocardial Infarction 01/2012 - 10/2002
7	Pulmonary Embolism 01/2014 - 05/2004
6	Infections 01/2019 - 01/2003
5	Body Weight (Weight, Body) 05/2019 - 08/2015
5	Aortic Dissection 01/2016 - 04/2005
5	Starvation 07/2011 - 05/2005
4	Insulin Resistance 05/2016 - 02/2007
4	Thrombosis (Thrombus) 01/2014 - 09/2004
4	Inflammation (Inflammations) 12/2013 - 04/2008
4	Heart Failure 11/2010 - 06/2006
4	Atrial Fibrillation 01/2008 - 07/2005
3	Muscular Atrophy (Muscle Atrophy) 01/2018 - 09/2009
3	Heart Rupture 11/2017 - 10/2002
3	Obesity 05/2016 - 03/2012
3	Fever (Fevers) 01/2016 - 09/2011
3	Ventricular Tachycardia 01/2015 - 10/2007
3	Pulmonary Edema 09/2014 - 01/2006
3	Necrosis 09/2013 - 01/2002
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 12/2012 - 12/2004
3	Respiratory Insufficiency (Respiratory Failure) 05/2012 - 02/2003
3	Sepsis (Septicemia) 02/2012 - 01/2002
3	Embolism (Embolus) 01/2012 - 09/2004
3	Acute Coronary Syndrome 05/2010 - 07/2005
3	Shock 01/2010 - 06/2004
3	Ventricular Fibrillation 01/2010 - 06/2004
3	Hypertension (High Blood Pressure) 05/2009 - 02/2003
3	Cardiovascular Diseases (Cardiovascular Disease) 11/2008 - 07/2005
3	Cardiogenic Shock 06/2006 - 10/2002
2	Dermatitis 01/2020 - 03/2011
2	Lymphoma (Lymphomas) 01/2018 - 07/2006
2	Wounds and Injuries (Trauma) 11/2017 - 07/2012
2	Heart Arrest (Cardiac Arrest) 11/2017 - 01/2010
2	T-Cell Leukemia (Leukemia, T Cell) 01/2017 - 12/2008
2	Breast Neoplasms (Breast Cancer) 01/2017 - 10/2014
2	Bacterial Infections (Bacterial Infection) 01/2016 - 12/2013
2	Prostatic Neoplasms (Prostate Cancer) 04/2015 - 01/2013
2	Tachycardia (Tachyarrhythmias) 01/2015 - 01/2010
2	Multiple Myeloma 01/2015 - 10/2010
2	Atrophy 04/2014 - 09/2009
2	Critical Illness (Critically Ill) 02/2014 - 02/2012
2	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 06/2012 - 06/2004
2	Ischemia 01/2012 - 06/2002
2	Acute Lung Injury 01/2012 - 01/2008
2	Septic Shock (Toxic Shock Syndrome) 01/2012 - 01/2006
2	Hemorrhage 01/2012 - 03/2006
2	Unstable Angina 11/2010 - 07/2005

Drug/Important Bio-Agent (IBA)

30	Proteins (Proteins, Gene)FDA Link 11/2021 - 03/2004
21	UbiquitinIBA 01/2020 - 01/2002
20	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2021 - 01/2002
10	Insulin (Novolin)FDA Link 02/2022 - 01/2002
9	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 10/2015 - 03/2003
6	ipragliflozinIBA 09/2020 - 02/2016
6	Ligases (Synthetase)IBA 10/2019 - 05/2005
5	PTEN-induced putative kinaseIBA 10/2018 - 10/2010
5	EnzymesIBA 01/2017 - 01/2003
5	Pharmaceutical PreparationsIBA 10/2014 - 01/2002
4	Sitagliptin Phosphate (Januvia)FDA Link 03/2020 - 03/2014
4	Hemoglobins (Hemoglobin)IBA 03/2020 - 05/2016
4	DNA (Deoxyribonucleic Acid)IBA 11/2018 - 08/2004
4	Biological ProductsIBA 07/2017 - 01/2002
4	Glucose (Dextrose)FDA LinkGeneric 02/2016 - 01/2002
4	Anti-Arrhythmia AgentsIBA 01/2010 - 01/2006
3	CytokinesIBA 01/2019 - 02/2003
3	Phosphotransferases (Kinase)IBA 03/2015 - 01/2012
3	Bortezomib (Velcade)FDA Link 01/2015 - 10/2010
3	ATP dependent 26S protease (26S proteasome)IBA 03/2013 - 06/2002
3	Interferon-gamma (Interferon, gamma)IBA 01/2013 - 05/2004
3	Troponin T (Troponin T1)IBA 05/2010 - 07/2005
3	nifekalantIBA 01/2010 - 07/2005
3	AntigensIBA 12/2009 - 05/2004
2	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 05/2019 - 05/2016
2	LipidsIBA 07/2017 - 04/2009
2	Sodium-Glucose Transporter 2 InhibitorsIBA 07/2017 - 05/2016
2	Hypoglycemic Agents (Hypoglycemics)IBA 05/2016 - 01/2002
2	SodiumIBA 02/2016 - 11/2008
2	Insulin-Like PeptidesIBA 04/2015 - 09/2009
2	Indicators and Reagents (Reagents)IBA 01/2015 - 12/2008
2	pro-brain natriuretic peptide (1-76)IBA 09/2014 - 05/2010
2	Dexmedetomidine FDA Link 02/2014 - 01/2006
2	Acetaminophen (Paracetamol)FDA LinkGeneric 04/2012 - 02/2012
2	Interleukin-6 (Interleukin 6)IBA 09/2011 - 04/2007
2	Amino Acids FDA Link 07/2011 - 05/2005
2	Valsartan (Vals)FDA Link 01/2011 - 05/2009
2	AlbuminsIBA 01/2011 - 06/2008
2	CreatinineIBA 01/2011 - 08/2006

Therapy/Procedure

16	Therapeutics 02/2022 - 10/2002
7	Catheters 02/2012 - 05/2004
5	Glycemic Control 03/2020 - 02/2016
4	Thrombectomy 01/2014 - 05/2004
3	Stents 01/2014 - 01/2012
3	Thrombolytic Therapy 01/2014 - 10/2002
3	Noninvasive Ventilation 05/2012 - 01/2008
3	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 01/2008 - 06/2004
3	Percutaneous Coronary Intervention 10/2006 - 10/2002
2	Extracorporeal Membrane Oxygenation 01/2012 - 01/2006